Professor

Professor
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Hoon Hyun / Ph.D.

· Position : Assistant Professor, Department of Biomedical Sciences, Chonnam National University Medical School

· Interesting field : Molecular Imaging, Drug Delivery System, Biomaterials

Tel+82-61-379-2652

Education

- 2008 - 2011: Ph.D., Japan Advanced Institute of Science and Technology, School of Materials Science
- 2005 - 2007: M.S., Chonbuk National University, Advanced Organic Materials Engineering
- 1999 - 2005: B.S., Chonbuk National University, Polymer/Nano Science and Technology

Experience

- 2015 - Present: Assistant Professor, Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju, South Korea
- 2014 - 2015: Research Associate, Department of Nuclear Medicine, Chonbuk National University Hospital, Jeonju, South Korea
- 2014 - 2014: Research Associate, Department of Molecular Science & Technology, Ajou University, Suwon, South Korea
- 2011 - 2014: Post-Doctoral Fellow, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
- 2009 - 2009: Visiting Student, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
- 2009 - 2009: Teaching Assistant, School of Materials Science, Japan Advanced Institute of Science and Technology (JAIST), Japan
- 2005 - 2007: Research Assistant, Biomaterials & Tissue Engineering Lab, Korea Research Institute of Chemical Technology (KRICT), South Korea

Honors and Award

- Best Poster Award, The Korean Society of Industrial and Engineering Chemistry (2017)
- Best Poster Award, The Korean Society for Biomaterials (2017)
- Young Investigator Award, Korean Tissue Engineering and Regeneration, The 15th annual conference, South Korea (2015)
- Summer Translational Research Fellowship ($25,000) from NIH U54 Award, Center for Future Technologies in Cancer Care at Boston University: Member of the National Institutes of Health Network, USA (2013)
- Japanese Government Scholarship (Full Cover for Ph.D. Degree), Japan (2007)

Academic Activity

- Member of The Korean Society for Biomaterials, The Korean Society of Industrial and Engineering Chemistry, Korean Tissue Engineering and Regenerative Medicine Society, The Polymer Society of Korea, The Pharmaceutical Society of Korea, Optical Society of Korea

Publications

- Seo KS, Hong KD, Hyun H, Kim MS, Khang G, Lee HB. Sustained release of proteins using temperature sensitive MPEG-PCL hydrogels. Tissue Eng Regen Med. 2005; 2(2):109-114.
- Cho YH, Hyun H, Lee JH, Jeong SC, Song IB, Lee B, Kim MS, Khang G, Rhee JM, Lee HB. Synthesis of triblock copolymers consisting of MPEG, PCL, and PLGA and determination of critical micelle concentration. Tissue Eng Regen Med. 2005; 2(4):368-377.
- Kim MS, Seo KS, Hyun H, Kim SK, Khang G, Lee HB. Sustained release of bovine serum albumin using implantable wafers prepared by MPEG-PLGA diblock copolymers. Int J Pharm. 2005; 304:165-177.
- Hyun H, Lee JH, Seo KS, Kim MS, Rhee JM, Lee HB, Khang G. Release of albumin from PLGA and PCL wafers containing natural and synthetic additives for protein delivery. Polymer-Korea. 2005; 29(5):468-474.
- Kim MS, Hyun H, Cho YH, Seo KS, Jang WY, Kim SK, Khang G, Lee HB. Preparation of MPEG-PCL via activated monomer mechanism and examination of micellar characterization. Polym Bull. 2005; 55:149-156.
- Cho MH, Kim SK, Hyun H, Shin YN, Kim MS, Lee B, Lee JS, Khang G, Lee HB, Lee I. Sustained release of BDNF using temperature sensitive MPEG-PCL hydrogels. Tissue Eng Regen Med. 2006; 3(1):46-51.
- Kim MS, Seo KS, Hyun H, Jeong SC, Seo SM, Lee JW, Lee B, Khang G, Lee HB. Controlled release of bovine serum albumin using MPEG-PCL diblock copolymers as implantable protein carriers. J Appl Polym Sci. 2006; 102:1561-1567.
- Kim MS, Hyun H, Seo KS, Cho YH, Lee JW, Lee CR, Khang G, Lee HB. Preparation and characterization of MPEG–PCL diblock copolymers with thermo-responsive sol-gel-sol phase transition. J Polym Sci, Part A: Polym Chem. 2006; 44:5413-5423.
- Kim MS, Hyun H (*co-1st author), Khang G, Lee HB. Preparation of thermosensitive diblock copolymers consisting of MPEG and polyesters. Macromolecules. 2006; 39(9):3099-3102.
- Hyun H, Kim MS, Khang G, Lee HB. Ring-opening polymerization of trimethylene carbonate by poly(ethylene glycol) in the presence of HCl∙Et2O as a monomer activator. J Polym Sci, Part A: Polym Chem. 2006; 44:4235-4241.
- Hyun H, Kim MS, Jeong SC, Kim YH, Lee SY, Khang G, Lee HB. Preparation of diblock copolymers consisting of MPEG and PCL/PLLA and their degradation property. Polym Eng Sci. 2006; 46:1242-49.
- Hyun H, Cho YH, Jeong SC, Lee B, Kim MS, Khang G, Lee HB. Synthesis and characterization of biodegradable MPEG-PCLA block copolymers. Polymer-Korea. 2006; 30(1):28-34.
- Hyun H, Kim MS, Khang G, Rhee JM, Lee HB. Synthesis and characterization of linear and branched copolymers of PEG and PCL. Polymer-Korea. 2006; 30(2):146-151.
- Hyun H, Yang JC, Kim MS, Lee HB, Khang G. Synthesis of MPEG/polyesters diblock copolymers and evaluation of micellar characterization as drug carrier. Polymer-Korea. 2006; 30(6):464-470.
- Kim SK, Hyun H, Kim SH, Yoon SJ, Kim MS, Rhee JM, Khang G, Lee HB. Osteogenic differentiation of bone marrow stem cells using thermo-sensitive hydrogels. Polymer-Korea. 2006; 30(3):196-201.
- Kim MS, Kim SK, Kim SH, Hyun H, Khang G, Lee HB. In vivo osteogenic differentiation of rat bone marrow stromal cells in thermosensitive MPEG-PCL diblock copolymer gels. Tissue Eng. 2006; 12 (10):2863-2873.
- Cho MH, Hyun H, Shin YN, Lee JW, Lee MS, Ahn HH, Kim MS, Lee B, Khang G, Lee HB. Release profile of BSA or BDNF from temperature sensitive hydrogels. Key Eng Mat. 2007; 342-343:473-476.
- Kim YH, Cho MH, Song IB, Hyun H, Lee JW, Kim MS, Seo SJ, Kang KW, Khang G, Yang SY, Lee HB. Injectable chitosan carrier for demineralized bone matrix. Key Eng Mat. 2007; 342-343:177-180.
- Lee JW, Hyun H, Cho JS, Kim MS, Khang G, Lee HB. The effect of crystallinity on release behavior of albumin from MPEG-polyesters vehicles. Tissue Eng Regen Med. 2007; 4(3):399-405.
- Hyun H, Kim YH, Lee JW, Kim MS, Khang G, Park K, Lee HB. In vitro and in vivo release of albumin from MPEG-PCL diblock copolymers as an in situ gel forming carrier. Biomacromolecules. 2007; 8:1093-1100.
- Hyun H, Cho JS, Kim BS, Lee JW, Kim MS, Khang G, Park K, Lee HB. Comparison of micelles formed by amphiphilic star block copolymers prepared in the presence of a nonmetallic monomer activator. J Polym Sci, Part A: Polym Chem. 2008; 46:2084–2096.
- Hyun H, Lee JW, Cho JS, Kim YH, Lee CR, Kim MS, Khang G, Lee HB. Polymeric nano-micelles using PEG and PTMC diblock copolymers as a drug carrier. Colloid Surface A. 2008; 313-314:131-135.
- Lee SY, Hyun H, Youn JY, Kim BS, Song IB, Kim MS, Lee B, Khang G, Lee HB. Preparation of nano-emulsified paclitaxel using MPEG-PLGA diblock copolymers. Colloid Surface A. 2008; 313-314: 126-130.
- Kim MS, Hyun H, Kim BS, Khang G, Lee HB. Polymeric nano-micelles as drug carrier using PEG and PTMC linear and star-shaped block copolymer. Curr Appl Phys. 2008; 8:646-650.
- Cho JS, Kim BS, Hyun H, Youn JY, Kim MS, Ko JH, Park YH, Khang G, Lee HB. Precise preparation of four-arm PEG-PTMC star block copolymers via activated monomer mechanism and examination of their solution properties. Polymer. 2008; 49:1777-1782.
- Kim BS, Oh JM, Hyun H (*co-1st author), Kim KS, Lee SH, Kim YH, Park K, Lee HB, Kim MS. Insulin-loaded microcapsules for in vivo delivery. Mol Pharmaceut. 2009; 6(2):353-365.
- Hyun H, Yui N. Mono-, di-, or tri-azidated cyclodextrin based polyrotaxanes for facile and efficient functionalization via click chemistry. Macromol Rapid Comm. 2011; 32:326-331.
- Hyun H, Yui N. Polyrotaxanes as a gene carrier. Polym Sci Tech. 2011; 22(1):14-16.
- Hyun H, Yui N. Ligand Accessibility to receptor binding sites enhanced by movable polyrotaxanes. Macromol Biosci. 2011; 11(6):765-771.
- Ehashi T, Hyun H, Yui N. Anti-inflammatory response of mannose-conjugated polyrotaxane endocytosed into macrophage. Macromol Res. 2011; 19(5);495-500.
- Choi HS, Nasr K, Alyabyev S, Feith D, Lee JH, Kim SH, Ashitate Y, Hyun H, Patonay G, Strekowski L, Henary M, Frangioni JV. Synthesis and in vivo fate of zwitterionic near-infrared fluorophores. Angew Chem Int Ed. 2011; 50(28):6258-6263.
- Lee JH, Hyun H, Cross C, Henary M, Nasr K, Oketokoun R, Choi HS, Frangioni JV. Rapid and facile microwave-assisted surface chemistry for functionalized microarray slides. Adv Funct Mater. 2012; 22:872-878.
- Hyun H, Bordo MW, Nasr K, Feith D, Lee JH, Kim SH, Ashitate Y, Moffitt L, Rosenberg M, Henary M, Choi HS, Frangioni JV. cGMP-compatible preparative scale synthesis of near-infrared fluorophores. Contrast Media & Mol Imaging. 2012; 7(6):516-524.
- Owens EA, Hyun H (co-1st author), Kim SH, Lee JH, Park G, Ashitate Y, Choi J, Hong GH, Alyabyev S, Lee SJ, Khang G, Henary M, Choi HS. Highly charged cyanine fluorophores for trafficking scaffold degradation. Biomed Mater. 2013; 8:014109.
- Kim SH, Park G, Hyun H, Lee JH, Ashitate Y, Choi J, Hong GH, Owens EA, Henary M, Choi, HS. Near-infrared lipophilic fluorophores for tracing tissue growth. Biomed Mater. 2013; 8:014110.
- Choi HS, Gibbs SL, Lee JH, Kim SH. Ashitate Y, Liu F, Hyun H, Park G, Xie Y, Bae S, Henary M, Frangioni JV. Targeted zwitterionic near-infrared fluorophores for improved optical imaging. Nat Biotechnol. 2013; 31(2):148-153.
- Kim SH, Lee JH, Hyun H, Ashitate Y, Park G, Robichaud K, Lunsford E, Lee SJ, Khang G, Choi HS. Near-infrared fluorescence imaging for noninvasive trafficking of scaffold degradation. Sci Rep. 2013; 3:1198.
- Lee JH, Park S, Hyun H, Bordo MW, Oketokoun R, Nasr KA, Frangioni JV, Choi HS. High-throughput screening of small molecule ligands targeted to live bacteria surface. Anal Chem. 2013; 85(7):3508-3514.
- Salim MM, Owens EA, Gao T, Lee JH, Hyun H, Choi HS, Henary M. Hydroxylated near-infrared BODIPY fluorophores as intracellular pH sensors. Analyst. 2014; 139(19):4862-4873.
- Ashitate Y, Hyun H (co-1st author), Kim SH, Lee JH, Henary M, Frangioni JV, Choi HS. Simultaneous mapping of pan and sentinel lymph nodes for real-time image-guided surgery. Theranostics. 2014; 4(7):693-700.
- Park MH, Hyun H (co-1st author), Ashitate Y, Park G, Lee JH, Njiojb C, Henary M, Frangioni JV, Choi HS. Prototype nerve-specific near-infrared fluorophores. Theranostics. 2014; 4(8):823-833.
- Hyun H, Wada H, Bao K. Gravier J, Yadav Y, Laramie M, Henary M, Frangioni JV, Choi HS. Phosphonated near-infrared fluorophores for biomedical imaging of bone. Angew Chem Int Ed. 2014; 53(40):10668-10672.
- Hyun H, Park SH, Kwon DY, Khang G, Lee HB, Kim MS. Thermo-responsive injectable MPEG-polyester diblock copolymers for sustained drug release. Polymers. 2014; 6(10):2670-2683.
- Jee JE, Lim J, Hyun H, Oon J, Ong YS, Massif C, Chang YT, Choi HS, Lee SS. Investigating fluorescence dyes in fluorescence-assisted screenings. Chem Commun. 2014; 50:15220-15223.
- Hyun H, Owens EA, Narayana L, Wada H, Gravier J, Bao K, Frangioni JV, Choi HS, Henary M. Central C-C bonding increases optical and chemical stability of NIR fluorophores. RSC Adv. 2014; 4:58762-58768.
- Wada H, Hyun H, Vargas C, Gravier J, Park G, Gioux S, Frangioni JV, Henary M, Choi HS. Pancreas-targeted NIR fluorophores for dual-channel image-guided abdominal surgery. Theranostics. 2015; 5(1):1-11.
- Hyun H, Park MH, Owens EA, Wada H, Henary M, Handgraaf HJM, Vahrmeijer AL, Frangioni JV, Choi HS. Structure-inherent targeting of near-infrared fluorophores for parathyroid and thyroid gland imaging. Nat Med. 2015; 21:192-197.
- Bao K, Nasr KA, Hyun H, Lee JH, Gravier J, Gibbs SL, Choi HS. Charge and hydrophobicity effects of NIR fluorophores on bone-specific imaging. Theranostics. 2015; 5(6):609-617.
- Njiojob C, Owens EA, Narayana L, Hyun H, Choi HS, Henary M. Tailored near-infrared contrast agents for image guided surgery. J Med Chem. 2015; 58(6):2845-2854.
- Wada H, Hyun H, Vargas C, Genega EM, Gravier J, Gioux S, Frangioni JV, Choi HS. Sentinel Lymph Node Mapping of Liver. Ann Surg Oncol. 2015; 22(3):1147-1155.
- Owens EA, Hyun H (co-1st author), Tawney JG, Choi HS, Henary M. Correlating molecular character of NIR imaging agents with tissue-specific uptake. J Med Chem. 2015; 58(10): 4348-4356.
- Hyun H, Owens EA, Park MH, Wada H, Frangioni JV, Henary M, Choi HS. Cartilage-specific near-infrared fluorophores for biomedical imaging. Angew Chem Int Ed. 2015; 54(30):8648-8652.
- Lee HJ, Lee SJ, Uthaman S, Thomas RG, Hyun H, Jeong YY, Cho CS, Park IK, Biomedical applications of magnetically functionalized organic/inorganic hybrid nanofibers. Int J Mol Sci. 2015; 16: 13661-13677.
- Kim KS, Hyun H, Yang JA, Lee MY, Kim H, Yun SH, Choi HS, Hahn SK, Bioimaging of Hyaluronate-interferon α conjugates using a non-interfering zwitterionic fluorophore. Biomacromolecules. 2015; 16(9): 3054-3061.
- Hyun H, Henary M, Gao T, Narayana L, Owens EA, Alyabyev S, Lee JH, Park G, Wada H, Ashitate Y, Bordo MW, Frangioni JV, Choi HS. 700-nm zwitterionic near-infrared fluorophores for dual-channel image-guided surgery. Mol Imaging Biol. 2016; 18(1): 52-61.
- Owens EA, Hyun H (co-1st author), Dost TL, Lee JH, Park G, Pham DH, Park MH, Choi HS, Henary M. Near-infrared illumination of native tissue for image-guided surgery. J Med Chem. 2016; 59(11):5311-5323.
- Ashitate Y, Levitz A, Park MH, Hyun H, Venugopal V, Park G, Fakhri GE, Henary M, Gioux S, Frangioni JV, Choi HS. Endocrine-specific NIR fluorophores for adrenal gland targeting. Chem Commun. 2016; 52(67):10305-10308.
- Garg P, Pandey S, Kim H, Seonwoo H, Park S, Choi KS, Jang K, Hyun H, Choung P, Kim J, Chung JH. Synergistic effects of hyperosmotic polymannitol based non-viral vectors and nanotopographical cues for enhanced gene delivery. RSC Adv. 2016; 6:111233-111238.
- Seonwoo H, Bae W, Park S, Kim HN, Choi KS, Lim KT, Hyun H, Kim JW, Kim J, Chung JH. Hierarchically micro- and nanopatterned topographical cues for modulation of cellular structure and function. IEEE T Nanobiosci. 2016; 15(8):835-842.
- Wada H, Hyun H, Kang H, Gravier J, Henary M, Bordo MW, Choi HS, Frangioni JV. Intraoperative near-infrared fluorescence imaging of thymus in preclinical models. Ann Thorac Surg. 2017; 103(4):1132-1141.
- Lee J, Park M, Ko Y, Kim B, Kim O, Hyun H, Kim D, Sohn H, Moon YL, Lim W. Ectopic overexpression of CD133 in HNSCC makes it resistant to commonly used chemotherapeutics. Tumor Biol. 2017; 39(4):1-12.
- Jo D, Hyun H.* Structure-inherent targeting of near-infrared fluorophores for image-guided surgery. Chonnam Med J. 2017; 53(2):95-102.
- Yun M, Kim DY, Lee JJ, Kim HS, Kim HS, Pyo A, Ryu Y, Kim TY, Zheng JH, Yoo SW, Hyun H, Oh G, Jeong J, Moon M, Min JH, Kwon SY, Kim JY, Chung E, Hong Y, Lee W, Kim HS, Min JJ. A high-affinity repebody for molecular imaging of EGFR-expressing malignant tumors. Theranostics. 2017; 7(10):2620-2633.
- Yoon SJ, Hyun H, Lee DW, Yang DH. Visible light-cured glycol chitosan hydrogel containing a beta-cyclodextrin-curcumin inclusion complex improves wound healing in vivo. Molecules. 2017; 22(9):1513.
- Lim W, Sohn H, Ko Y, Park M, Kim B, Jo D, Jung JS, Yang DH, Kim J, Kim OJ, Kim D, Moon YL, Min JJ, Hyun H.* Real-time in vivo imaging of metastatic bone tumors with a targeted near-infrared fluorophore. Oncotarget. 2017; 8(39):65770-65777.
- Pham DH, Kim JS, Kim SK, Shin DJ, Uong NT, Hyun H, Yoon MS, Kang SJ, Ryu YJ, Cho JS, Yoon JH, Lee JS, Cho D, Lee SH, Park MH. Effects of ADAM10 and ADAM17 inhibitors on natural killer cell expansion and antibody-dependent cellular cytotoxicity against breast cancer cells in vitro. Anticancer Res. 2017; 37(10):5507-5513.
- Lee S, Lim W, Ryu HW, Jo D, Min JJ, Kim HS, Hyun H.* ZW800-1 for assessment of blood-brain barrier disruption in a photothrombotic stoke model. Int J Med Sci. 2017; 14(13):1430-1435.
- Lee DW, Jo J, Jo D, Kim J, Min JJ, Yang DH, Hyun H.* Supramolecular assembly based on host-guest interaction between beta-cyclodextrin and adamantane for specifically targeted cancer imaging. J Ind Eng Chem. 2018; 57:37-44.
- Kim D, Park M, Jang H, Hyun H, Lim W. Chemoresistance to 5-FU inhibited by 635 nm LED irradiation in CD133+ KB cell line. Lasers Med Sci. 2018; in press.
- Park MH, Lim W, Jo D, Jung JS, Kim S, Kim J, Lim HS, Lee JS, Min JJ, Hyun H.* Rapid differential diagnosis of breast microcalcification using targeted near-infrared fluorophores. Adv Healthc Mater. 2018; in press.
List

Professor 목록

Professor 목록
Jung-Joon (John) Min / M.D.,Ph.D.more

· Position : Professor and Chair, Department of Nuclear Medicine, Chonnam National University Medical School & Hwasun Hospital

· Interesting field : Molecular Imaging, Theranostics, Nuclear Oncology, Bacterio Therapy

Tel+82-61-379-2876

Hee-Seung (Henry) Bom / M.D.,Ph.D.more

· Position : Professor, Department of Nuclear Medicine, Chonnam National University Medical School & Hospital

· Interesting field : Nuclear Cardiology, Radioiodine therapy, Biomedical Informatics

Tel+82-61-379-7270

Changho Lee / Ph.D.more

· Position : Assistant Professor, Department of Nuclear Medicine, Chonnam National University Medical School & Hwasun Hospital

· Interesting field : Biomedical Optical Imaging, Molecular Imaging, Quantitative Analysis & Signal Processing

Tel+82-61-379-2885

Seong Young Kwon / M.D.,Ph.D.more

· Position : Associate Professor, Department of Nuclear Medicine, Chonnam National University Hwasun Hospital

· Interesting field : Radionuclide Therapy, Molecular Imaging, Theranostics

Tel+82-61-379-7273

Sae-Ryung Kang / M.D.more

· Position : Assistant Professor, Department of Nuclear Medicine, Chonnam National University Hwasun Hospital

· Interesting field : Cancer Imaging, Infection Imaging, Pain Imaging

Tel+82-61-379-7267

Jahae Kim / M.D.,Ph.D.more

· Position : Assistant Professor, Department of Nuclear Medicine, Chonnam National University Hospital

· Interesting field : Nuclear Medicine, Radioisotope Therapy Etc.

Tel+82-62-220-5648

Sang-Geon Cho / M.D.more

· Position : Contract Professor, Department of Nuclear Medicine, Chonnam National University Hospital

· Interesting field : Nuclear Cardiology

Tel+82-62-220-5648

Su Woong Yoo / M.D.,Ph.D.more

· Position : Contract Professor, Department of Nuclear Medicine, Chonnam National University Hwasun Hospital

· Interesting field : Nuclear Medicine, Molecular Imaging, Biomedical Optics

Tel+82-61-379-7276

Dong-Yeon Kim / Ph.D.more

· Position : Assistant professor, Department of Nuclear Medicine, Chonnam National University Medical School & Hwasun Hospital

· Interesting field : Development of Radiopharmaceuticals, Molecular Imaging, Radioisotope Labeling

Tel+82-61-379-7268/ 2872

Hyon E. Choy / Ph.D.more

· Position : Professor, Dept. of Microbiology

· Interesting field : Molecular microbiology, Bacteriotherapy

Tel+82-61-379-2742

Yeong Jin Hong / Ph.D.more

· Position : Professor, Department of Microbiology, Chonnam National University Medical School

· Interesting field : Development of Microbiology, Development of Molecular Biology

Tel+82-61-379-2746

Hoon Hyun / Ph.D.more

· Position : Assistant Professor, Department of Biomedical Sciences, Chonnam National University Medical School

· Interesting field : Molecular Imaging, Drug Delivery System, Biomaterials

Tel+82-61-379-2652

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