Previous List Next

Yeong Jin Hong / Ph.D.

· Position : Professor, Department of Microbiology, Chonnam National University Medical School

· Interesting field : Development of Microbiology, Development of Molecular Biology



- 1996.04 - 2000.03 : Ph.D in Medical Science, Osaka University School of Medicine, Osaka University (supervised by Prof. Taroh Kinoshita).
- 1992.03 - 1994.02: MS in Biotechnology, Department of Life Science (now renamed as Department of Biological Sciences),
Korea Advanced Institute of Science and Technology (KAIST) (supervised by Prof. Changwon Kang).
- 1986.03 - 1992.02: BS in Biochemistry, Yonsei University (Seoul, Korea)


- 2011.03 - Present: Professor, Department of Microbiology, Chonnam National University Medical School
- 2006.03 - 2011.02: Associate Professor, Department of Microbiology, Chonnam National University Medical School
- 2003.02 - 2006.02: Assistant Professor, Department of Microbiology, Chonnam National University Medical School
- 2011.08 - 2012.08: Visiting scientist, Department of radiology, Stanford University Medical School supervised by Prof. Sanjiv Sam Gambhir
- 2002.04 - 2003.02: Post-doc, Department of Cell Biology, Albert Einsein College of Medicine of Yeshiva University (New York, USA) supervised by Prof. Pamela Stanley
- 2000.04 - 2002.03: Post-doc, JSPS fellow, Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University (Osaka, Japan). supervised by Prof. Taroh Kinoshita
- 1994.10 - 1996.01: Research Assistant, Samsung Biomedical Research Institute (Seoul, Korea)
- 1994.03 - 1994.09: Research Assistant, Genetic engineering Research Institute (now renamed Korea Research Institute of Bioscience and Biotechnology) (Taejon, Korea)

Honors and Award

- 2000.04 - 2002.03: JSPS postdoctoral fellowship for foreign researcher (Japan society for promotion of science, Japan)
- 1996.01 - 2000.03: Japanese Government (Munbusho) scholarship (Japan)
- 1992.03 - 1994.02: Korea Government Scholarship (KAIST, Korea)
- 1987.03 - 1992.02: Jongha Scholarship from KCC Co., Korea


- Kim JE, Phan TX, Nguyen VH, Dinh-Vu HV, Zheng JH, Yun M, Park SG, Hong Y, Choy HE, Szardenings M, Hwang W, Park JA, Park S, Im SH, Min JJ. “Salmonella typhimurium Suppresses Tumor Growth via the Pro-Inflammatory Cytokine Interleukin-1β.” Theranostics. 2015 Oct 6;5(12):1328-42.
- Phan TX, Nguyen VH, Duong MT, Hong Y, Choy HE, Min JJ. “Activation of inflammasome by attenuated Salmonella typhimurium in bacteria-mediated cancer therapy.” Microbiol Immunol. 2015 Nov;59(11):664-75.
- Park SH, Park S, Kim DY, Pyo A, Kimura RH, Sathirachinda A, Choy HE, Min JJ, Gambhir SS, Hong Y. “Isolation and Characterization of a Monobody with a Fibronectin Domain III Scaffold That Specifically Binds EphA2.” PLoS One. 2015 Jul 15;10(7):e0132976.
- Hong H, Lim D, Kim GJ, Park SH, Sik Kim H, Hong Y, Choy HE, Min JJ. “Targeted deletion of the ara operon of Salmonella typhimurium enhances L-arabinose accumulation and drives PBAD-promoted expression of anti-cancer toxins and imaging agents.” Cell Cycle. 2014;13(19):3112-20.
- Zhu X, Li J, Hong Y, Kimura RH, Ma X, Liu H, Qin C, Hu X, Hayes TR, Benny P, Gambhir SS, Cheng Z. “99mTc-Labeled Cystine Knot Peptide Targeting Integrin αvβ6 for Tumor SPECT Imaging.” Mol Pharm. 2014 Apr 7;11(4):1208-17.
- Jeong JH, Kim K, Lim D, Jeong K, Hong Y, Nguyen VH, Kim TH, Ryu S, Lim JA, Kim JI, Kim GJ, Kim SC, Min JJ, Choy HE. “Anti-tumoral effect of the mitochondrial target domain of Noxa delivered by an engineered Salmonella typhimurium.” PLoS One. 2014 Jan 8;9(1):e80050.
- Park SJ, Park SH, Cho S, Kim DM, Lee Y, Ko SY, Hong Y, Choy HE, Min JJ, Park JO, Park S. “New paradigm for tumor theranostic methodology using bacteria-based microrobot.” Sci Rep. 2013 Dec 2;3:3394.
- Jiang SN, Park SH, Lee HJ, Zheng JH, Kim HS, Bom HS, Hong Y, Szardenings M, Shin MG, Kim SC, Ntziachristos V, Choy HE, Min JJ. “Engineering of bacteria for the visualization of targeted delivery of a cytolytic anticancer agent.” Mol Ther. 2013 Nov;21(11):1985-95.
- Kim K, Jeong JH, Lim D, Hong Y, Yun M, Min JJ, Kwak SJ, Choy HE. “A novel balanced-lethal host-vector system based on glmS.” PLoS One. 2013;8(3):e60511.
- Yun M, Pan S, Jiang SN, Nguyen VH, Park SH, Jung CH, Kim HS, Min JJ, Choy HE, Hong Y. “Effect of Salmonella treatment on an implanted tumor (CT26) in a mouse model.” J Microbiol. 2012 Jun;50(3):502-10
- Jeong JH, Kim HJ, Kim KH, Shin M, Hong Y, Rhee JH, Schneider TD, Choy HE. “An unusual feature associated with LEE1 P1 promoters in enteropathogenic Escherichia coli (EPEC).” Mol Microbiol. 2012 Feb;83(3):612-22.
- Le UN, Kim HS, Kwon JS, Kim MY, Nguyen VH, Jiang SN, Lee BI, Hong Y, Shin MG, Rhee JH, Bom HS, Ahn Y, Gambhir SS, Choy HE, Min JJ. “Engineering and visualization of bacteria for targeting infarcted myocardium.” Mol Ther. 2011 May;19(5):951-9
- Park SI, Jeong JH, Choy HE, Rhee JH, Na HS, Lee TH, Her M, Cho KO, Hong Y. “Immune response induced by ppGpp-defective Salmonella enterica serovar Gallinarum in chickens.” J Microbiol. 2010 Oct;48(5):674-81
- Huang LJ, Cui J, Piao HH, Hong Y, Choy HE, Ryu PY. “Molecular cloning and characterization of clyA genes in various serotypes of Salmonella enterica.” J Microbiol. 2010 Oct;48(5):663-7.
- Piao HH, Tam VT, Na HS, Kim HJ, Ryu PY, Kim SY, Rhee JH, Choy HE, Kim SW, Hong Y. “Immunological responses induced by asd and wzy/asd mutant strains of Salmonella enterica serovar Typhimurium in BALB/c mice.” J Microbiol. 2010 Aug;48(4):486-95
- Jiang SN, Phan TX, Nam TK, Nguyen VH, Kim HS, Bom HS, Choy HE, Hong Y, Min JJ. “Inhibition of tumor growth and metastasis by a combination of Escherichia coli-mediated cytolytic therapy and radiotherapy.” Mol Ther. 2010 Mar;18(3):635-42
- Nguyen VH, Kim HS, Ha JM, Hong Y, Choy HE, Min JJ. “Genetically engineered Salmonella typhimurium as an imageable therapeutic probe for cancer.” Cancer Res. 2010 Jan 1;70(1):18-23.
- Cui J, Piao H, Jin S, Na HS, Hong Y, Choy HE, Ryu PY. “Effect of iron on cytolysin A expression in Salmonella enterica serovar Typhi.” J Microbiol. 2009 Aug;47(4):479-85.
- Seong J, Piao HH, Ryu PY, Kim YU, Choy HE, Hong Y. “Expression of c-Myc is related to host cell death following Salmonella typhimurium infection in macrophage.” J Microbiol. 2009 Apr;47(2):214-9.
- Min JJ, Nguyen VH, Kim HJ, Hong Y, Choy HE. “Quantitative bioluminescence imaging of tumor-targeting bacteria in living animals.” Nat Protoc. 2008;3(4):629-36.
- Min JJ, Kim HJ, Park JH, Moon S, Jeong JH, Hong YJ, Cho KO, Nam JH, Kim N, Park YK, Bom HS, Rhee JH, Choy HE. “Noninvasive real-time imaging of tumors and metastases using tumor-targeting light-emitting Escherichia coli.” Mol Imaging Biol. 2008 Jan-Feb;10(1):54-61. Epub 2007 Nov 10.
- Kim YU, Hong Y. “Functional analysis of the first mannosyltransferase (PIG-M) involved in glycosylphosphatidylinositol synthesis in Plasmodium falciparum.” Mol Cells. 2007 Oct 31;24(2):294-300.
- Kim YU, Ashida H, Mori K, Maeda Y, Hong Y, Kinoshita T. “Both mammalian PIG-M and PIG-X are required for growth of GPI14-disrupted yeast.” J Biochem. 2007 Jul;142(1):123-9. Epub 2007 May 22.
- Park SJ, Kim GY, Choy HE, Hong YJ, Saif LJ, Jeong JH, Park SI, Kim HH, Kim SK, Shin SS, Kang MI, Cho KO. “Dual enteric and respiratory tropisms of winter dysentery bovine coronavirus in calves.” Arch Virol. 2007;152(10):1885-900. Epub 2007 Jun 14.
- Kang KH, Song JA, Shin DJ, Choy HE, Hong Y. “Identification of genes differentially expressed in RAW264.7 cells infected by Salmonella typhimurium using PCR method.” J Microbiol. 2007 Feb;45(1):29-33.
- Shin DJ, Kang JY, Kim YU, Yoon JS, Choy HE, Maeda Y, Kinoshita T, Hong Y. “Isolation of new CHO cell mutants defective in CMP-sialic acid biosynthesis and transport.” Mol Cells. 2006 Dec 31;22(3):343-52.
- Shin DJ, Cho D, Kim YR, Rhee JH, Choy HE, Lee JJ, Hong Y. “Diagnosis of paroxysmal nocturnal hemoglobinuria by fluorescent clostridium septicum alpha toxin.” J Mol Microbiol Biotechnol. 2006;11(1-2):20-7.
- Na HS, Kim HJ, Lee HC, Hong Y, Rhee JH, Choy HE. “Immune response induced by Salmonella typhimurium defective in ppGpp synthesis. Vaccine. 2006 Mar 15;24(12):2027-34.
- Shin M, Song M, Rhee JH, Hong Y, Kim YJ, Seok YJ, Ha KS, Jung SH, Choy HE. “DNA looping-mediated repression by histone-like protein H-NS: specific requirement of Esigma70 as a cofactor for looping.” Genes Dev 2005 Oct 1;19(19):2388-98.
- Murakami Y, Siripanyaphinyo U, Hong Y, Tashima Y, Maeda Y, Kinoshita T. “The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component.” Mol Biol Cell 2005 Nov;16(11):5236-46
- Hong Y, Kang JY, Kim YU, Shin DJ, Choy HE, Maeda Y, Kinoshita T. “New mutant Chinese hamster ovary cell representing an unknown gene for attachment of glycosylphosphatidylinositol to proteins.” Biochem Biophys Res Commun 2005 Oct 7;335(4):1060-9.
- Shin DJ, Choy HE, Hong Y. “Use of Clostridium septicum alpha toxins for isolation of various glycosylphosphatidylinositol-deficient cells.” J Microbiol 2005 Jun;43(3):266-71.
- Ashida H., Hong Y., Murakami Y., Shishioh N., Sugimoto N., Kim Y. U., Maeda Y., Kinoshita T. “Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I.” Mol Biol Cell 2005 Mar;16(3):1439-48.
- Hong Y., Shishioh N., Ohishi K., Ashida H., Maeda Y., Kinoshita T. “GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol.” J Biol Chem 2005 Mar 11;280(10):9728-34. [1st co-author]
- Kang J. Y., Hong Y., Ashida H., Shishioh N., Murakami Y., Morita Y. S., Maeda Y., Kinoshita T. “PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol.” J Biol Chem 2005 Mar 11;280(10):9489-97
- Shin DJ, Lee JJ, Choy HE, Hong Y. “Generation and characterization of Clostridium septicum alpha toxin mutants and their use in diagnosing paroxysmal nocturnal hemoglobinuria” Biochem Biophys Res Commun 2004 Nov 12;324(2):753-60
- Hong Y, Sundaram S, Shin DJ, Stanley P. “The Lec23 Chinese hamster ovary mutant is a sensitive host for detecting mutations in alpha-glucosidase I that give rise to congenital disorder of glycosylation IIb (CDG IIb).” J Biol Chem 2004 Nov 26;279(48):49894-901.
- Song, M., Kim, H. J., Kim, E. Y., Shin, M., Lee, H. Hong, Y., Rhee, J. H., Ryu, S., Lim, S., Choy, H. “ppGpp-dependent stationary phase induction of genes on salmonella pathogenicity island 1 (SPI1)” J Biol Chem 2004 Aug 13;279(33):34183-90.
- Hong, Y. and Stanley P. “Lec3 Chinese hamster ovary mutants lack UDP-N-acetylglucosamine 2-epimerase activity because of mutations in the epimerase domain of the Gne gene” J Biol Chem 2003 Dec 26;278(52):53045-53054.
- Murakami, Y., Siripanyapinyo, U., Hong, Y., Kang, J.Y., Ishihara, S., Nakakuma, H., Maeda, Y., Kinoshita, T. “PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor” Mol Biol Cell 2003 Oct;14(10):4285-4295.
- Hong, Y., Ohishi, K., Kang, J. Y., Tanaka, S., Inoue, N., Nishimura, J., Maeda, Y. and Kinoshita, T. “Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins.” Mol Biol Cell 2003 May 1;14(5):1780-1789
- Hong, Y., Ohishi, K., Inoue, N., Kang, J. Y., Shime, H., Horiguchi, H., van der Goot, F. G., Sugimoto, N. and Kinoshita, T. “Requirement of N-glycan on GPI-anchored proteins for efficient binding of aerolysin but not Clostridium septicum alpha-toxin” EMBO J 2002 oct 1;21(19):5047-5056
- Abrami L., Velluz M.C., Hong Y., Ohishi K., Mehlert A., Ferguson M., Kinoshita T., Gisou van der Goot F. “The glycan core of GPI-anchored proteins modulates aerolysin binding but is not sufficient: the polypeptide moiety is required for the toxin-receptor interaction.” FEBS Lett 2002 Feb 13;512(1-3):249-54.
- Yada T., Sugiura R., Kita A., Itoh Y., Lu Y., Hong Y., Kinoshita T., Shuntoh H., Kuno T. “Its8, a fission yeast homolog of Mcd4 and Pig-n, is involved in GPI anchor synthesis and shares an essential function with calcineurin in cytokinesis” J Biol Chem 2001 Apr 27;276(17):13579-86
- Maeda Y., Watanabe R., Harris C. L., Hong Y., Ohishi K, Kinoshita K., Kinoshita T. “PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER.” EMBO J 2001 Jan 15;20(1-2):250-61.
- Hong Y., Maeda Y., Watanabe R., Inoue N., Ohishi K., Kinoshita T. “Requirement of PIG-F and PIG-O for Transferring Phosphoethanolamine to the Third Mannose in Glycosylphosphatidylinositol” J Biol Chem 2000 Jul 7; 275 (27), 20911-20919
- Hong Y., Maeda Y., Watanabe R., Ohishi K., Mishkind, M., Riezman H., Kinoshita T. “Pig-n, a mammalian homologue of yeast Mcd4p, is involved in transferring phosphoethanolamine to the first mannose of the glycosylphosphatidylinositol” J Biol Chem 1999 Dec 3; 274 (49), 35099-35106
- Hong Y, Ohishi K., Watanabe R., Endo Y., Maeda Y., Kinoshita T. “GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis” J Biol Chem 1999 Jun 25; 274 (26), 18582-18588
- Hong Y., Ohishi K., Inoue N., Endo Y., Fujita T., Takeda J., Kinoshita T. “Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1” Genomics 1997 Sep 15; 44 (3), 347-349
- Kim S. S., Hong Y., Kang C. “Effects of multiple mutations at the conserved TATA sequence of bacteriophage SP6 promoter on transcription efficiency” Biochem Mol Biol Intl 1993 Sep; 31 (1), 153-159

Degree thesis
- Hong. Y., PhD thesis, 2000 Mar: "GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis" supervised by Prof. Taroh Kinoshita) in Osaka University School of Medicine, Osaka, Japan
- Hong. Y., MS thesis, 1994 Feb: "In vitro termination efficiency change depending on sequence and distance in the elongation path" supervised by Prof. Changwon Kang in Department of Life Science, KAIST, Taejon, Korea

이메일주소 무단수집 거부

본 웹사이트에 게시된 이메일 주소가 전자우편 수집 프로그램이나 그 밖의 기술적 장치를 이용하여 무단으로 수집되는 것을 거부하며 이를 위반시 정보 통신망법에 의해 형사처벌 됨을 유의하시기 바랍니다.


팀뷰어 설치파일 다운받기